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Pragmatic trials are those that are designed to inform real-world clinical practice. They are often characterized by their focus on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Pragmatic, a software company provides a variety of casino games on online gambling platforms. Its iGaming solutions are used by the most reputable operators as well as land-based casinos. The company provides front-end site design tools, analysis tools and promotions, marketing, security payment systems, customer service and bug-reporting. In addition, the company provides its users a safe environment with high-quality graphics and gaming.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and reduces bias in the results. However, too much heterogeneity can result in problems with the trial design.
Pragmatic Play is also a major player on the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in various variations. The company's live studios in Romania and Malta provide a genuine gambling experience for players and offer a wide range of virtual betting options. The company also offers a variety of games that make online gambling fun and interactive. Some of these shows feature live hosts, whereas others are hosted by prominent personalities from the industry.
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Pragmatic Play offers not only mobile-friendly slot machines but also table games and live casino. The company is licensed by several regulatory bodies such as Malta Gaming Authority and UK Gambling Commission. The company's games are secured with high-end encryption, and its security team is on hand to assist players in any situation.
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Legality
Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software can be used on mobile devices and in a variety of languages. Despite its relative youth it has established itself as a leading gaming platform for casinos. Wolves is one of the latest games that is a 5-reel slot machine that has a high RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used in lieu for explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decisions. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the features of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, as well as the follow-up.
There is a positive increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to keep in mind that the majority of studies were conducted in primary care settings.